Trametinib Hydroxy Impurity

CAT: 1596-AR-T05673-02Size: 25 UnitsDry Ice: NoHazardous: No

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CAT#:1596-AR-T05673-02Size:25 Units

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

871700-24-2

Synonyms

3-cyclopropyl-1- (2-fluoro-4-iodophenyl) -5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7 (1H,3H,8H) -trione

Molecular Formula

C18H15FIN3O4

Molecular Weight

483.24

API Name

Trametinib

Chemical Information

3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido(2,3-d)pyrimidine-2,4,7(1H,3H,8H)-trione

CAS Number	871700-24-2
PubChem CID	59717004
IUPAC Name	3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7-trione
Molecular Formula	C18H15FIN3O4
Molecular Weight	483.2
XLogP	2.4
Topological Polar Surface Area	81.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Heavy Atom Count	27
Formal Charge	0
Complexity	806

SMILES

CC1=C(C2=C(N(C1=O)C)N(C(=O)N(C2=O)C3CC3)C4=C(C=C(C=C4)I)F)O

InChI

InChI=1S/C18H15FIN3O4/c1-8-14(24)13-15(21(2)16(8)25)23(12-6-3-9(20)7-11(12)19)18(27)22(17(13)26)10-4-5-10/h3,6-7,10,24H,4-5H2,1-2H3

InChIKey

MHHFXMZMCYWCJQ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 871700-24-2

CID: 59717004

Formula: C18H15FIN3O4

MW: 483.2

Interactive 3D Structure

Loading 3D structure...

Computed Properties

Property	Value
Molecular Weight	483.2
XLogP3	2.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	483.00913
Monoisotopic Mass	483.00913
Topological Polar Surface Area	81.2 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	806
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Catalog	Name
AR-T05669-01	Trametinib Impurity 10
AR-T05665-01	Trametinib Impurity 4
AR-T05664-01	Trametinib Impurity 2
AR-T05667-01	Trametinib Impurity 8
AR-T05671-01	Trametinib Impurity 1
AR-T05674-01	Trametinib Desacetyl Impurity
AR-T05668-01	Trametinib Impurity 9
AR-T05666-01	Trametinib Impurity 7
AR-T06320-01	Trametinib Cyclopropanamide Impurity
AR-T02750-01	Trametinib

Catalog	Name
CS-O-44951	Trametinib Hydroxy impurity
CS-O-60271	Trametinib Impurity 7
CS-O-53869	Trametinib Impurity 11
CS-O-44950	Trametinib Anilide impurity
CS-O-43264	Trametinib Impurity 5
CS-EO-04096	Trametinib Cyclopropanamide Impurity
RM-T180538-01	Trametinib Impurity 38
RM-T180513-01	Trametinib Impurity 13
RM-T180515-01	Trametinib Impurity 15
RM-T180518-01	Trametinib Impurity 18