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Biguanide

CAT: 0804-HY-121006-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121006-01Size:5 mg
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Description
Biguanide is an orally active antihyperglycemic agent. Biguanide inhibits mitochondrial ATP production, activates the LKB1-AMPK signaling pathway, and damages the energy homeostasis. Biguanide enhances insulin-receptor activation and downstream signaling. Biguanide exhibits potential in ameliorating the type 2 diabetes and the insulin-associated cancers[1].
CAS Number
56-03-1
UNSPSC
12352211
Hazard Statement
H302-H315-H318-H335
Target
AMPK; Insulin Receptor; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/biguanide.html
Purity
98.07
Solubility
DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
NC(NC(N)=N)=N
Molecular Formula
C2H7N5
Molecular Weight
101.11
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Pollak M. Metformin and other biguanides in oncology: advancing the research agenda. Cancer Prev Res (Phila) . 2010 Sep;3 (9) :1060-5.|[2]Di Magno, L., et al., (2022) . The Mechanism of Action of Biguanides: New Answers to a Complex Question. Cancers, 14 (13), 3220.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4

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