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A-331440

CAT: 0804-HY-12191Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12191Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A-331440 is a potent and selective histamine H3 receptor antagonist that regulates neurotransmitter release by inhibiting presynaptic H3 receptors. In preclinical studies involving mice on a high-fat diet, A-331440 demonstrated dose-dependent effects on weight reduction and fat loss. At 5 mg/kg, it effectively decreased body weight comparable to dexfenfluramine, while at 15 mg/kg, it significantly reduced body fat and improved insulin tolerance, similar to mice on a low-fat diet. These findings suggest that A-331440 holds promise as an antiobesity agent by modulating histaminergic pathways involved in food intake and metabolic regulation[1].
CAS Number
392338-13-5
UNSPSC
12352005
Hazard Statement
H319
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/a-331440.html
Smiles
CN(C)[C@H](CC1)CN1CCCOC2=CC=C(C3=CC=C(C=C3)C#N)C=C2
Molecular Formula
C22H27N3O
Molecular Weight
349.47
Precautions
P264-P280-P305+P351+P338
References & Citations
[1]Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
B7698-10A 331440 dihydrochloride
sc-252330A-331440 dihydrochloride

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