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Furagin

CAT: 0804-HY-77036-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-77036-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Furagin (Furazidine), an analogue of Nitrofurantoin , is an antibiotic with antibacterial activity against ESKAPE pathogens with MIC values of 0-32 µg/mL. Furagin inhibits human Carbonic anhydrases. Furagin is promising for research of cancer and urinary tract infections (UTIs)[2][3][4][5].
CAS Number
1672-88-4
Product Name Alternative
Furazidine; Furazidin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial; Carbonic Anhydrase
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Furagin.html
Purity
99.84
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C1NC(CN1/N=C/C=C/C2=CC=C(O2)[N+]([O-])=O)=O
Molecular Formula
C10H8N4O5
Molecular Weight
264.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Mannisto P, et al. Pharmacokinetics of furagin, a new nitrofurantoin congener, on human volunteers. Int J Clin Pharmacol Biopharm. 1979 Jun;17 (6) :264-70.|[2]Slapsyte G, et al. Cytogenetic analysis of children under long-term antibacterial therapy with nitroheterocyclic compound furagin. Mutat Res. 2001 Apr 5;491 (1-2) :25-30.|[3]Pustenko A, et al. The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35 (1) :1011-1020.|[4]Osterman IA, et al. Sorting Out Antibiotics' Mechanisms of Action: a Double Fluorescent Protein Reporter for High-Throughput Screening of Ribosome and DNA Biosynthesis Inhibitors[J]. Antimicrob Agents Chemother. 2016 Nov 21;60 (12) :7481-7489.|[5]Sapegin A, et al. Novel 5-Nitrofuran-Tagged Imidazo-Fused Azines and Azoles Amenable by the Groebke-Blackburn-Bienaymé Multicomponent Reaction: Activity Profile against ESKAPE Pathogens and Mycobacteria. Biomedicines. 2022 Sep 6;10 (9) :2203.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CA IX; CA XII

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