Isorhamnetin

• Description :

  Isorhamnetin is a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L.. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3K.

• Product Name Alternative :

  3'-Methylquercetin

• UNSPSC :

  12352005

• Hazard Statement :

  H351

• Target :

  Endogenous Metabolite; MEK; PI3K

• Type :

  Natural Products

• Related Pathways :

  MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer; Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/Isorhamnetin.html

• Purity :

  99.94

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1C(O)=C(C2=CC=C(O)C(OC)=C2)OC3=CC(O)=CC(O)=C13

• Molecular Formula :

  C16H12O7

• Molecular Weight :

  316.26

• Precautions :

  H351

• References & Citations :

  [1]Kim JE, et al. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. Cancer Prev Res (Phila) . 2011 Apr;4 (4) :582-91.|[2]Hu S, et al. Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogen activated protein kinase kinase signaling pathways. Mol Med Rep. 2015 Nov;12 (5) :6745-51.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  MEK1; PI3K

• CAS Number :

  [480-19-3]