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Eltrombopag (Olamine)

CAT: 0804-HY-15306A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15306A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Eltrombopag Olamine (Eltrombopag diethanolamine salt) is an orally active thrombopoietin receptor nonpeptide agonist. Eltrombopag Olamine owns thrombopoietic activity, and has been used to research low blood platelet counts with chronic immune thrombocytopenia. Eltrombopag Olamine can be used for the research of cardiovascular. Eltrombopag Olamine also has highly inhibitory effects against multidrug resistant Staphylococcus aureus. Eltrombopag Olamine can induce apoptosis in hepatocellular carcinomab (HCC) as well[1][2][3][4][5].
CAS Number
496775-62-3
Product Name Alternative
Eltrombopag diethanolamine salt; SB-497115GR
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Bacterial; Thrombopoietin Receptor
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Eltrombopag-Olamine.html
Purity
99.96
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(C1=CC(C2=CC=CC(N/N=C3C(C)=NN(C4=CC=C(C)C(C)=C4)C/3=O)=C2O)=CC=C1)O.NCCO.NCCO
Molecular Formula
C29H36N6O6
Molecular Weight
564.63
Precautions
H302, H315, H319, H335
References & Citations
[1]Erickson-Miller CL, et al. Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells. 2009 Feb;27 (2) :424-30.|[2]Erickson-Miller CL, et al. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp Hematol. 2005 Jan;33 (1) :85-93.|[3]Lee H, et al. Repurposing Eltrombopag for Multidrug Resistant Staphylococcus aureus Infections. Antibiotics (Basel) . 2021 Nov 9;10 (11) :1372.|[4]Juan Zhu, et al. Identification of Eltrombopag as a Repurposing Drug Against Staphylococcus epidermidis and its Biofilms. Curr Microbiol. 2021 Feb 21.|[5]Kurokawa T, et al. The Eltrombopag antitumor effect on hepatocellular carcinoma. Int J Oncol. 2015 Nov;47 (5) :1696-702.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Eur J Clin Pharmacol. 2022 Oct;78 (10) :1657-1666.|Front Pharmacol. 2020 Nov 16:11:582625.|ACS Nano. 2024 Sep 10;18 (36) :24872-24897.|Acta Neuropathol Commun. 2025 Nov 4;13 (1) :223.|Alzheimers Res Ther. 2024 Jun 3;16 (1) :121.|Biomed Pharmacother. 2025 Jun 20:189:118246.|bioRxiv. 2025 March 03.|bioRxiv. 2025 Sep 13.|Blood Adv. 2017 Feb 28;1 (7) :468-476.|BMC Cancer. 2020 Nov 30;20 (1) :1171.|Cell Death Discov. 2024 Oct 26;10 (1) :453.|Cells. 2022 Jan 18;11 (3) :319.|Curr Microbiol. 2021 Apr;78 (4) :1159-1167.|Eur J Pharmacol. 2024 Oct 29:177086.|J Pharm Biomed Anal. 2023 Oct 25:235:115683.|J Thromb Haemost. 2022 Aug;20 (8) :1900-1909.|J Transl Med. 2025 Jan 22;23 (1) :103.|Virology. 2023 Aug:585:205-214.|Viruses. 2019 Apr 25;11 (4) :385.

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