Gliquidone (Standard)

CAT: 0804-HY-B1114R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1114R-01Size:5 mg
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Description
Gliquidone (Standard) is the analytical standard of Gliquidone. This product is intended for research and analytical applications. Gliquidone can bind to the pancreatic β-cells and increases insulin release to regulate blood glucose levels. Gliquidone significantly decreases LPS (HY-D1056) -induced proinflammatory responses and inhibits ERK/STAT3/NF-κB phosphorylation in BV2 microglial cells. Gliquidone can suppress microgliosis, microglial hypertrophy mediated by LPS, and proinflammatory cytokine COX-2 and IL-6 levels in murine model. Gliquidone also exhibits good anticancer activity in lung carcinoma cells. Gliquidone has antioxidant property. Gliquidone can be studied in research for type 2 diabetes and cancers[1][2].
CAS Number
[33342-05-1]
Product Name Alternative
AR-DF 26 (Standard)
UNSPSC
12352005
Target
COX; ERK; Interleukin Related; NF-κB; Potassium Channel; Reference Standards; STAT
Type
Reference Standards
Related Pathways
Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; NF-κB; Others; Stem Cell/Wnt
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gliquidone-standard.html
Smiles
O=S(C1=CC=C(CCN(C(C(C)(C)C2=C3C=C(OC)C=C2)=O)C3=O)C=C1)(NC(NC4CCCCC4)=O)=O
Molecular Formula
C27H33N3O6S
Molecular Weight
527.63
References & Citations
[1]Kim, J., et al., (2021) . The Anti-diabetic Drug Gliquidone Modulates Lipopolysaccharide-Mediated Microglial Neuroinflammatory Responses by Inhibiting the NLRP3 Inflammasome. Frontiers in aging neuroscience, 13, 754123. |[2]M. Shamona, et al., Vibrational spectra of second generation antidiabetic drug gliquidone exhibiting anticancer activity, antioxidant activity using both the experimental and theoretical approach, Journal of Molecular Liquids, Volume 411, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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