Gliquidone (Standard)

• Description :

  Gliquidone (Standard) is the analytical standard of Gliquidone. This product is intended for research and analytical applications. Gliquidone can bind to the pancreatic β-cells and increases insulin release to regulate blood glucose levels. Gliquidone significantly decreases LPS (HY-D1056) -induced proinflammatory responses and inhibits ERK/STAT3/NF-κB phosphorylation in BV2 microglial cells. Gliquidone can suppress microgliosis, microglial hypertrophy mediated by LPS, and proinflammatory cytokine COX-2 and IL-6 levels in murine model. Gliquidone also exhibits good anticancer activity in lung carcinoma cells. Gliquidone has antioxidant property. Gliquidone can be studied in research for type 2 diabetes and cancers[1][2].

• Product Name Alternative :

  AR-DF 26 (Standard)

• UNSPSC :

  12352005

• Target :

  COX; ERK; Interleukin Related; NF-κB; Potassium Channel; Reference Standards; STAT

• Type :

  Reference Standards

• Related Pathways :

  Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; NF-κB; Others; Stem Cell/Wnt

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/gliquidone-standard.html

• Smiles :

  O=S(C1=CC=C(CCN(C(C(C)(C)C2=C3C=C(OC)C=C2)=O)C3=O)C=C1)(NC(NC4CCCCC4)=O)=O

• Molecular Formula :

  C27H33N3O6S

• Molecular Weight :

  527.63

• References & Citations :

  [1]Kim, J., et al., (2021) . The Anti-diabetic Drug Gliquidone Modulates Lipopolysaccharide-Mediated Microglial Neuroinflammatory Responses by Inhibiting the NLRP3 Inflammasome. Frontiers in aging neuroscience, 13, 754123. |[2]M. Shamona, et al., Vibrational spectra of second generation antidiabetic drug gliquidone exhibiting anticancer activity, antioxidant activity using both the experimental and theoretical approach, Journal of Molecular Liquids, Volume 411, 2024.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [33342-05-1]