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Recombinant Human Epithelial cell adhesion molecule (EPCAM), partial

CAT: 0399-CSB-EP007717HUc7-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0399-CSB-EP007717HUc7-01Size:20 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Product Name Alternative
Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein; Epithelial glycoprotein 314; KS 1/4 antigen; KSA; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1
Abbreviation
Recombinant Human EPCAM protein, partial
Gene Name
EPCAM
UniProt
P16422
Expression Region
24-265aa
Organism
Homo sapiens (Human)
Target Sequence
QEECVCENYKLAVNCFVNNNRQCQCTSVGAQNTVICSKLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDESGLFKAKQCNGTSMCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSKSLRTALQKEITTRYQLDPKFITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKGESLFHSKKMDLTVNGEQLDLDPGQTLIYYVDEKAPEFSMQGLK
Tag
C-terminal 6xHis-tagged
Type
In Stock Protein
Source
E.coli
Field of Research
Tags & Cell Markers
Relevance
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E
Endotoxin
Not test
Purity
Greater than 95% as determined by SDS-PAGE.
Activity
Not Test
Form
Liquid or Lyophilized powder
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Molecular Weight
34.3 kDa
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Protein Length
Partial

UniProtKB · P16422

Epithelial cell adhesion molecule

EPCAM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P16422
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EPCAM
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Ep-CAM
EC number
—
Processing
Precursor
Secondary accessions
P18180, Q6FG26, Q6FG49, Q96C47, Q9UCD0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Cellular component

Cell junctionCell membraneMembraneTight junction

Disease

Disease variantHereditary nonpolyposis colorectal cancer

PTM

Disulfide bondGlycoprotein

Domain

RepeatSignalTransmembraneTransmembrane helix

Molecular function

Tumor antigen

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