Irisolidone

• Description :

  Irisolidone is a major isoflavone found in Pueraria lobata flowers. Irisolidone exhibits potent hepatoprotective activity. Irisolidone shows the high efficacy for volume-regulated anion channels (VRAC) blockade (IC50=9.8 μM) [1][2][3].

• CAS Number :

  [2345-17-7]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Chloride Channel

• Type :

  Natural Products

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/irisolidone.html

• Purity :

  99.39

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1C(C2=CC=C(OC)C=C2)=COC3=CC(O)=C(OC)C(O)=C13

• Molecular Formula :

  C17H14O6

• Molecular Weight :

  314.29

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Kim SY, et al. Irisolidone, an isoflavone metabolite, represses JC virus gene expression via inhibition of Sp1 binding in human glial cells. Biochem Biophys Res Commun. 2006 May 26;344 (1) :3-8.|[2]Zhang G, et al. Pharmacokinetics of irisolidone and its main metabolites in rat plasma determined by ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Nov 15;1005:23-9.|[3]Xue Y, et al. Natural and synthetic flavonoids, novel blockers of the volume-regulated anion channels, inhibit endothelial cell proliferation. Pflugers Arch. 2018 Oct;470 (10) :1473-1483.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported