EphB1-IN-1

• Description :

  EphB1-IN-1 (Compound 1) is a potent EphB1 inhibitor with IC50s of 3.0, 15 and 220 nM against EphB1G703C, EphB1T697G and EphB1WT, respectively[1].

• Product Name Alternative :

  GW876167 hydrochloride; BVT-933 hydrochloride, GW876167; BVT-942

• UNSPSC :

  12352005

• Target :

  EGFR

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/ephb1-in-1.html

• Purity :

  99.87

• Solubility :

  DMSO : 150 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1=CC2=NC=NC(NC3=CC(O)=CC=C3Cl)=C2C=C1)CCl

• Molecular Formula :

  C16H12Cl2N4O2

• Molecular Weight :

  363.20

• References & Citations :

  [1]Kung A, et al. A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases. ACS Chem Biol. 2017 Jun 16;12 (6) :1499-1503.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1980036-18-7]