Phytosphingosine-d7

CAT: 0804-HY-W011303S-01Size: 500 µgDry Ice: NoHazardous: No
CAT#:0804-HY-W011303S-01Size:500 µg
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Description
Phytosphingosine-d7 (4-Hydroxysphinganine-d7) is deuterium labeled Phytosphingosine. Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC50 value of 33.4 μM and can be used in the study of type II diabetes[1][2][3][4][5].
Product Name Alternative
4-Hydroxysphinganine-d7
UNSPSC
12352211
Target
Apoptosis; Endogenous Metabolite; Free Fatty Acid Receptor; Fungal; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; GPCR/G Protein; Metabolic Enzyme/Protease; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology
Smiles
OC[C@@H]([C@@H]([C@@H](CCCCCCCCCCCC([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])O)O)N
Molecular Formula
C18H32D7NO3
Molecular Weight
324.55
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]1. Pavicic T, Wollenweber U, Farwick M, et al. Anti‐microbial and‐inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris[J]. International journal of cosmetic science, 2007, 29 (3) : 181-190.|[3]Cai Q, et al. Phytosphingosine inhibits the growth of lung adenocarcinoma cells by inducing G2/M-phase arrest, apoptosis, and mitochondria-dependent pathway cell death in vitro and in vivo. Chem Biol Interact. 2024 Jan 5;387:110795.|[4]Glenz R, et al. The major plant sphingolipid long chain base phytosphingosine inhibits growth of bacterial and fungal plant pathogens. Sci Rep. 2022 Jan 20;12 (1) :1081. |[5]Nagasawa T, et al. Phytosphingosine is a novel activator of GPR120. J Biochem. 2018 Jul 1;164 (1) :27-32.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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