6-ROX

CAT: 0804-HY-D0053-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-D0053-01Size:5 mg
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Description
6-ROX is a selective fluorescent probe and potential inhibitor of COX-2. 6-ROX binds to the active site of COX-2 and inhibits its conversion of arachidonic acid into prostaglandins. 6-ROX is often used in the field of optical imaging related to tumors and inflammation, and helps detect diseased tissues with high expression of COX-2[1][2].
CAS Number
[194785-18-7]
Product Name Alternative
6-Carboxy-X-rhodamine
UNSPSC
12171500
Hazard Statement
H315, H319, H335
Target
Fluorescent Dye
Type
Dye Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/6-ROX.html
Concentration
10mM
Purity
98.43
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C(O)=O)C(C(C2=CC3=C4N(CCC3)CCCC4=C2[O+]=C56)=C5C=C7CCCN8CCCC6=C87)=C1)[O-]
Molecular Formula
C33H30N2O5
Molecular Weight
534.60
Precautions
H315, H319, H335
References & Citations
[1]Uddin MJ, et al. Design, synthesis, and structure-activity relationship studies of fluorescent inhibitors of cycloxygenase-2 as targeted optical imaging agents. Bioconjug Chem. 2013 Apr 17;24 (4) :712-23.|[2]Butkevich AN, et al. Hydroxylated Fluorescent Dyes for Live-Cell Labeling: Synthesis, Spectra and Super-Resolution STED. Chemistry. 2017 Sep 7;23 (50) :12114-12119.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

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