6-ROX

• Description:

  6-ROX is a selective fluorescent probe and potential inhibitor of COX-2. 6-ROX binds to the active site of COX-2 and inhibits its conversion of arachidonic acid into prostaglandins. 6-ROX is often used in the field of optical imaging related to tumors and inflammation, and helps detect diseased tissues with high expression of COX-2[1][2].

• Product Name Alternative:

  6-Carboxy-X-rhodamine

• UNSPSC:

  12171500

• Hazard Statement:

  H315, H319, H335

• Target:

  Fluorescent Dye

• Type:

  Dye Reagents

• Related Pathways:

  Others

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/6-ROX.html

• Concentration:

  10mM

• Purity:

  98.43

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC=C(C(O)=O)C(C(C2=CC3=C4N(CCC3)CCCC4=C2[O+]=C56)=C5C=C7CCCN8CCCC6=C87)=C1)[O-]

• Molecular Formula:

  C33H30N2O5

• Molecular Weight:

  534.60

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Uddin MJ, et al. Design, synthesis, and structure-activity relationship studies of fluorescent inhibitors of cycloxygenase-2 as targeted optical imaging agents. Bioconjug Chem. 2013 Apr 17;24 (4) :712-23.|[2]Butkevich AN, et al. Hydroxylated Fluorescent Dyes for Live-Cell Labeling: Synthesis, Spectra and Super-Resolution STED. Chemistry. 2017 Sep 7;23 (50) :12114-12119.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Dye Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  [194785-18-7]