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Oxomemazine

CAT: 0804-HY-136587-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136587-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Oxomemazine is a phenothiazine-based histamine H1-receptor blocker. Oxomemazine is a selective antagonist for muscarinic M1 receptor, displays about 20-fold difference in the affinity for high (Ki = 84 nM, M1 receptor) and low (Ki = 1.65 μM, M2 receptor) affinity sites. Oxomemazine is an antihistamine and anticholinergic agent used for the study of cough treatment. Oxomemazine is protective against anaphylactic microshock in guinea pigs[1][2][3].
CAS Number
3689-50-7
UNSPSC
12352005
Hazard Statement
H301, H311, H330
Target
Histamine Receptor; mGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/oxomemazine.html
Purity
99.18
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(CN1C2=C(C=CC=C2)S(C3=CC=CC=C13)(=O)=O)CN(C)C
Molecular Formula
C18H22N2O2S
Molecular Weight
330.44
Precautions
H301, H311, H330
References & Citations
[1]S W Lee, et al.Selectivity of oxomemazine for the M1 muscarinic receptors.Arch Pharm Res. 1994 Dec;17 (6) :443-51.|[2]M S Siddegowda, et al.Oxomemazine hydro-chloride. Acta Crystallogr Sect E Struct Rep Online. 2011 Aug 1;67 (Pt 8) :o1875.|[3]HERXHEIMER H, et al. THE EFFECT OF SOME NEW ANTIHISTAMINES ON THE ANAPHYLACTIC MICROSHOCK OF THE GUINEA-PIG. Br J Pharmacol Chemother. 1963 Dec;21 (3) :414-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H1 Receptor; mGluR1; mGluR2

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