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Crolibulin

CAT: 0804-HY-13603-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13603-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Crolibulin (EPC2407) is a tubulin polymerization inhibitor, with potent apoptosis induction and cell growth inhibition. Crolibulin has anti-tumor activity. Crolibulin also has cardiovascular toxicity and neurotoxicity[1][2][3].
CAS Number
1000852-17-4
Product Name Alternative
EPC2407
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Crolibulin.html
Concentration
10mM
Purity
98.96
Solubility
DMSO : 125 mg/mL (ultrasonic; warming)
Smiles
N#CC1=C(N)OC2=C(N)C(N)=CC=C2[C@H]1C3=CC(OC)=C(OC)C(Br)=C3
Molecular Formula
C18H17BrN4O3
Molecular Weight
417.26
Precautions
H302, H315, H319
References & Citations
[1]Kalmuk J, et al. Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer. Oncotarget. 2015 Sep 15;6 (27) :24376-92.|[2]Zhai X, et al. Discovery and Optimization of Novel 5-Indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrile Derivatives as Potent Antitubulin Agents Targeting Colchicine-binding Site. Sci Rep. 2017 Feb 27;7:43398.|[3]S. P. Anthony, et al. EPC2407, a new beta-tubulin vascular disrupting agent with potent apoptosis and cell growth inhibition. Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007) 14043-14043.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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