SingleFlowEx TCR Cbeta1 PE

SingleFlowEx TCR Cbeta1 PE

• Description: SingleFlowEx is fluorochrome-labeled monoclonal antibody single reagent for use in laboratory-developed multicolor flow cytometry tests in order to examine human clinical samples. SingleFlowEx can be used in various multicolor combinations. Laboratory shall establish the SingleFlowEx performance characteristics in conjunction with other reagents in normal and pathological samples.
• Certification: RUO, GMP
• Clone: JOVI.1
• Validated Applications: FC
• Concentration: 0.040 mg/mL
• Format: PE
• Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Components: 1 vial of monoclonal antibody reagent. The content (1 mL) is sufficient for min. 100 Tests.
• References & Citations: *Huppa JB, Ploegh HL: In vitro translation and assembly of a complete T cell receptor-CD3 complex. J Exp Med. 1997 Aug 4186(3):393-403. , URL: https://www.ncbi.nlm.nih.gov/pubmed/9236191,*Viney JL, Prosser HM, Hewitt CR, Lamb JR, Owen MJ: Generation of monoclonal antibodies against a human T cell receptor beta chain expressed in transgenic mice. Hybridoma. 1992 Dec11(6):701-13. , URL: https://www.ncbi.nlm.nih.gov/pubmed/1284120,*San José E, Alarcón B: Receptor engagement transiently diverts the T cell receptor heterodimer from a constitutive degradation pathway. J Biol Chem. 1999 Nov 19274(47):33740-6., URL: https://pubmed.ncbi.nlm.nih.gov/10559266/,*Pasare C, Mukherjee P, Verhoef A, Bansal P, Mendiratta SK, George A, Lamb JR, Rath S, Bal V: T cells in mice expressing a transgenic human TCR beta chain get positively selected but cannot be activated in the periphery by signaling through TCR. Int Immunol. 2001 Jan13(1):53-62., URL: https://pubmed.ncbi.nlm.nih.gov/11133834/,*Martin EP, Arnaud J, Alibaud L, Gouaillard C, Llobera R, Huchenq-Champagne A, Rubin B: Molecular mechanisms in the TCR (TCR alpha beta-CD3 delta epsilon, gamma epsilon) interaction with zeta 2 homodimers: clues from a 'phenotypic revertant' clone. Int Immunol. 1999 Jul11(7):1005-15., URL: https://pubmed.ncbi.nlm.nih.gov/10383932/,*Horna P, Shi M, Olteanu H, Johansson U: Emerging role of T-cell receptor constant β chain-1 (TRBC1) expression in the flow cytometric diagnosis of T-cell malignancies. Int J Mol Sci. 2021 Feb 1222(4):1817., URL: https://pubmed.ncbi.nlm.nih.gov/33673033/,*Use of this product has not been published., URL: ,
• Storage Conditions: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.