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GDC-0623

CAT: 1596-AR-G01155-02Size: 25 UnitsDry Ice: NoHazardous: No
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CAT#:1596-AR-G01155-02Size:25 Units
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CAS Number
1168091-68-6
Synonyms
5- ((2-fluoro-4-iodophenyl) amino) -N- (2-hydroxyethoxy) imidazo[1,5-a]pyridine-6-carboxamide; GDC-0623; (5- ((2-Fluoro-4-Iodophenyl) amino) -N- (2-Hydroxyethoxy) imidazo[1,5-a]pyridine-6-Carboxamide)
Molecular Formula
C16H14FIN4O3
Molecular Weight
456.22
API Name
Gdc-0623

Chemical Information

Gdc-0623

GDC-0623 is a member of the class of imidazopyridines that is imidazo[1,5-a]pyridine substituted by (2-fluoro-4-iodophenyl)amino and (2-hydroxyethoxy)aminoacyl groups at positions 5 and 6. It is a potent ATP non-competitive inhibitor of MEK1 (Ki = 0.13nM) and also has efficacy against both mutant BRAF and mutant KRAS. It is in clinical development for treatment of patients with locally advanced or metastatic solid tumors. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor. It is a primary alcohol, an organoiodine compound, an imidazopyridine, a substituted aniline, a secondary amino compound, a hydroxamic acid ester and a member of monofluorobenzenes.

CAS Number1168091-68-6
PubChem CID42642654
IUPAC Name5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
Molecular FormulaC16H14FIN4O3
Molecular Weight456.21
XLogP3.7
Topological Polar Surface Area87.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count25
Formal Charge0
Complexity461
SMILES
C1=CC(=C(C=C1I)F)NC2=C(C=CC3=CN=CN32)C(=O)NOCCO
InChI
InChI=1S/C16H14FIN4O3/c17-13-7-10(18)1-4-14(13)20-15-12(16(24)21-25-6-5-23)3-2-11-8-19-9-22(11)15/h1-4,7-9,20,23H,5-6H2,(H,21,24)
InChIKey
RFWVETIZUQEJEF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Gdc-0623
CAS: 1168091-68-6
CID: 42642654
Formula: C16H14FIN4O3
MW: 456.21
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight456.21
XLogP33.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass456.00947
Monoisotopic Mass456.00947
Topological Polar Surface Area87.9 Ų
Heavy Atom Count25
Formal Charge0
Complexity461
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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474102GDC 0623

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