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SpiD3

CAT: 0804-HY-163607-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-163607-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SpiD3, a spirocyclic dimer, is an anticancer agent. SpiD3 markedly inhibits malignant B-cell proliferation and suppressed NF-κB activation independent of TME-associated stimuli. SpiD3 induces apoptosis and inhibits protein synthesis in chronic lymphocytic leukemia cells. SpiD3 can be used for study of chronic lymphocytic leukemia (CLL) [1].
CAS Number
3033533-25-1
UNSPSC
12352005
Target
Apoptosis; NF-κB
Type
Reference compound
Related Pathways
Apoptosis; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/spid3.html
Purity
98.24
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1OC2(CC1=C)C(N(CCCN3C(C4(C5=C3C=CC=C5)OC(C(C4)=C)=O)=O)C6=C2C=CC=C6)=O
Molecular Formula
C27H22N2O6
Molecular Weight
470.47
References & Citations
[1]Eiken AP, et al. Novel Spirocyclic Dimer, SpiD3, Targets Chronic Lymphocytic Leukemia Survival Pathways with Potent Preclinical Effects. Cancer Res Commun. 2024;4 (5) :1328-1343.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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