Pseudolaric Acid B

CAT: 0804-HY-N6939-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N6939-01Size:5 mg
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Description
Pseudolaric Acid B is an orally active diterpene acid. Pseudolaric Acid B has anti-fungal, anti-fertility, anti-angiogenesis and anticancer activity, and can induce tumor cell apoptosis and autophagy. In addition, Pseudolaric Acid B can inhibit the secretion of hepatitis B virus (HBV) and has immunosuppressive effect, selectively inhibiting the proliferation of T lymphocytes and the production of IL-2[1][2][3][4][5].
CAS Number
[82508-31-4]
UNSPSC
12352005
Hazard Statement
H301, H361
Target
Apoptosis; Autophagy; Ferroptosis; Fungal; HBV; HIF/HIF Prolyl-Hydroxylase; Interleukin Related
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pseudolaric-acid-b.html
Concentration
10mM
Purity
99.47
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=CC[C@@]([C@@](CC1)(OC(C)=O)[C@]2([H])[C@@](C)(/C=C/C=C(C(O)=O)\C)O3)(CC2)C3=O)OC
Molecular Formula
C23H28O8
Molecular Weight
432.46
Precautions
H301, H361
References & Citations
[1]Wang WC, et al. [Endocrine activity of pseudolaric acids A and B and their effects on sex hormones, prostaglandins, uteri, and fetuses]. Zhongguo Yao Li Xue Bao. 1991 Mar;12 (2) :187-90.|[2]Wei N, et al. The immunosuppressive activity of pseudolaric acid B on T lymphocytes in vitro. Phytother Res. 2013 Jul;27 (7) :980-5.|[3]Yu J, et al. Pseudolaric acid B inhibits the secretion of hepatitis B virus. Oncol Rep. 2017 Jan;37 (1) :519-525.|[4]Yu J, et al. Pseudolaric acid B activates autophagy in MCF-7 human breast cancer cells to prevent cell death. Oncol Lett. 2016 Mar;11 (3) :1731-1737.|[5]Li MH, et al. Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation. Clin Cancer Res. 2004 Dec 15;10 (24) :8266-74.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HIF-1α

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