Haloperidol decanoate

CAT: 0804-HY-107969-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-107969-01Size:5 mg
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Description
Haloperidol decanoate is a depot preparation of haloperidol, a commonly used butyrophenone derivative with antipsychotic activity. Haloperidol decanoate can increase the striatal D2 receptor in rat. Haloperidol decanoate can improve conditions of psychoses (mainly schizophrenia) . Haloperidol decanoate can lead to increased accumulation of the dopamine metabolites homo-vanillic acid. Haloperidol decanoate can reduce intestinal transport, increase gastric emptying and reduce acid output in rat model[1][4].
CAS Number
[74050-97-8]
UNSPSC
12352005
Hazard Statement
H302, H413
Target
COX; Dopamine Receptor; NO Synthase
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/haloperidol-decanoate.html
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCCCCCC(OC1(C2=CC=C(Cl)C=C2)CCN(CCCC(C3=CC=C(F)C=C3)=O)CC1)=O
Molecular Formula
C31H41ClFNO3
Molecular Weight
530.11
Precautions
H302, H413
References & Citations
[1]R Beresford, et al. Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in psychosis. Drugs. 1987 Jan;33 (1) :31-49.|[2]Schmitz, I., et al., (2025) . A single dose of haloperidol decanoate induces short-term hippocampal neuroinflammation: focus on the glial response. Pharmacological reports : PR, 77 (3), 800–808. |[3]Oh-e, Y., et al., (1991) . Pharmacokinetics of haloperidol decanoate in rats. Journal of pharmacobio-dynamics, 14 (11), 615–622.|[4]Akiyama, K., et al., (1987) . Effect of chronic administration of haloperidol (intermittently) and haloperidol-decanoate (continuously) on D2 dopamine and muscarinic cholinergic receptors and on carbachol-stimulated phosphoinositide hydrolysis in the rat striatum. The Japanese journal of psychiatry and neurology, 41 (2), 311–320.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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