Haloperidol decanoate

• Description:

  Haloperidol decanoate is a depot preparation of haloperidol, a commonly used butyrophenone derivative with antipsychotic activity. Haloperidol decanoate can increase the striatal D2 receptor in rat. Haloperidol decanoate can improve conditions of psychoses (mainly schizophrenia) . Haloperidol decanoate can lead to increased accumulation of the dopamine metabolites homo-vanillic acid. Haloperidol decanoate can reduce intestinal transport, increase gastric emptying and reduce acid output in rat model[1][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H413

• Target:

  COX; Dopamine Receptor; NO Synthase

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/haloperidol-decanoate.html

• Purity:

  99.67

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CCCCCCCCCC (OC1 (C2=CC=C (Cl) C=C2) CCN (CCCC (C3=CC=C (F) C=C3) =O) CC1) =O

• Molecular Formula:

  C31H41ClFNO3

• Molecular Weight:

  530.11

• Precautions:

  H302, H413

• References & Citations:

  [1]R Beresford, et al. Haloperidol decanoate. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in psychosis. Drugs. 1987 Jan;33 (1) :31-49.|[2]Schmitz, I., et al., (2025) . A single dose of haloperidol decanoate induces short-term hippocampal neuroinflammation: focus on the glial response. Pharmacological reports : PR, 77 (3), 800–808. |[3]Oh-e, Y., et al., (1991) . Pharmacokinetics of haloperidol decanoate in rats. Journal of pharmacobio-dynamics, 14 (11), 615–622.|[4]Akiyama, K., et al., (1987) . Effect of chronic administration of haloperidol (intermittently) and haloperidol-decanoate (continuously) on D2 dopamine and muscarinic cholinergic receptors and on carbachol-stimulated phosphoinositide hydrolysis in the rat striatum. The Japanese journal of psychiatry and neurology, 41 (2), 311–320.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  74050-97-8