IFN-alpha 2/IFNA2, Rhesus Macaque (HEK293, His)

IFN-alpha 2/IFNA2, Rhesus Macaque (HEK293, His)

• UNSPSC Description: IFN-alpha 2 (IFNA2), belongs to type I interferon family, is a protein secreted by cells infected by a virus and acting on other cells to inhibit viral infection[1]. IFN-alpha 2 exerts cytotoxic activity against CD8+ T cells and induces CD4+ T cell depletion[3]. IFN-alpha 2/IFNA2 Protein, Rhesus Macaque (HEK293, His) contains 188 a.a. (M1-E188), is produced in HEK293 cells with a C-terminal His-tag.
• Type: Recombinant Proteins
• Assay Protocol: https://www.medchemexpress.com/cytokines/ifn-alpha-2-ifna2-protein-rhesus-macaque-hek293-his.html
• Purity: 95.00
• Smiles: CDLPQTHSLG NRRTLMLLAQ MRRISLFFCL KDRHDFEFPQ EEFGNQFQKA QTIPVLHEMI QQTFNLFSTK DSSAAWDETL LNKFYTELYQ QLNDLEACVM QEMGVTETPL MNKNSILAVR KYFQRITLYL KEKKYSLCAW EVVRAEIMRS FSLSTNLQES LRSKE
• Molecular Weight: Approximately 19-23 kDa
• References & Citations: [1]Abraham S, et al. Gene therapy with plasmids encoding IFN-β or IFN-α14 confers long-term resistance to HIV-1 in humanized mice. Oncotarget. 2016 Nov 29;7(48):78412-78420.|[2]Zhang SY, et al. Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense. Immunol Rev. 2008 Dec;226:29-40.|[3]Sutter K, et al. Interferon α subtypes in HIV infection. Cytokine Growth Factor Rev. 2018 Apr;40:13-18.|[4]Watanabe H, et al. Detailed structure of mouse interferon α2 and its interaction with Sortilin. J Biochem. 2021 Oct 11;170(2):265-273.|[5]Gull I, et al. Heterologous expression, immunochemical and computational analysis of recombinant human interferon alpha 2b. Springerplus. 2013 Jun 15;2(1):264.|[6]Paul F, et al. IFNA2: The prototypic human alpha interferon. Gene. 2015 Aug 10;567(2):132-7.
• Shipping Conditions: Blue Ice
• Storage Conditions: Stored at -20°C for 2 years