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Phloracetophenone

CAT: 0804-HY-W008226-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W008226-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity[1]. Phloracetophenone stimulats bile secretion mediated through Mrp2[2].
CAS Number
480-66-0
Product Name Alternative
2,4,6-trihydroxyacetophenone; 1- (2,4,6-Trihydroxyphenyl) ethanone
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial; Cytochrome P450
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Phloracetophenone.html
Purity
99.98
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic)
Smiles
CC(=O)C1=C(O)C=C(O)C=C1O
Molecular Formula
C8H8O4
Molecular Weight
168.15
Precautions
H302, H315, H319, H335
References & Citations
[1]Charoenteeraboon J, et al. Induction of human cholesterol 7alpha-hydroxylase in HepG2 cells by 2,4,6-trihydroxyacetophenone. Eur J Pharmacol. 2005 May 16;515 (1-3) :43-6.|[2]Piyachaturawat P, et al. Choleretic activity of phloracetophenone in rats: structure-function studies using acetophenone analogues. Eur J Pharmacol. 2000 Jan 10;387 (2) :221-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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