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Scytonemin

CAT: 0804-HY-112356-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112356-01Size:5 mg
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Description
Scytonemin is a hydrophobic alkaloid pigment that can be isolated from the outer sheath of cyanobacteria. Scytonemin has protective function against short-wave solar ultraviolet (UV) radiation, which can reduce the generation of reactive oxygen species (ROS) and the formation of DNA damage. Scytonemin also has anti-inflammatory and anti-proliferative activities, produces concentration-dependent inhibition (IC50=2.0 μM) of polo-like kinase 1 (PLK1) -mediated cdc25C phosphorylation, and plays an important role in regulating the G2/M transition in the cell cycle. It can be used in the research of cancer, acute inflammation and sunscreen cosmetics[1][2][3][4][5].
CAS Number
152075-98-4
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Apoptosis; Polo-like Kinase (PLK) ; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/scytonemin.html
Purity
99.53
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(/C1=C\C2=CC=C(O)C=C2)C(C(C(/C3=C\C4=CC=C(O)C=C4)=O)=C5C3=NC6=C5C=CC=C6)=C7C1=NC8=C7C=CC=C8
Molecular Formula
C36H20N2O4
Molecular Weight
544.56
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Proteau PJ, et al. The structure of scytonemin, an ultraviolet sunscreen pigment from the sheaths of cyanobacteria. Experientia. 1993 Sep 15;49 (9) :825-9.|[2]Rastogi RP, et al. Cyanobacterial Sunscreen Scytonemin: Role in Photoprotection and Biomedical Research. Appl Biochem Biotechnol. 2015 Jul;176 (6) :1551-63.|[3]Gerwick, et al. "Antimutagenic, antiinflammatory, and potential anticancer substances from marine algae." Food Factors for Cancer Prevention. Springer Japan, 1997.|[4]Stevenson, et al. "The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore." Journal of Pharmacology and Experimental Therapeutics 303.2 (2002) : 858-866.|[5]Degenhardt, et al. "Targeting Polo-like kinase in cancer therapy." Clinical cancer research 16.2 (2010) : 384-389.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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