Alcaftadine

CAT: 0804-HY-17039-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-17039-01Size:5 mg
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Description
Alcaftadine (R89674) is a histamine H1 receptor antagonist, which is used to prevent eye irritation brought on by allergic conjunctivitis. Alcaftadine is a broad-spectrum antihistamine displaying a high affinity for histamine H1 and H2 receptors and a lower affinity for H4 receptors. Alcaftadine also exhibits modulatory action on immune cell recruitment and mast cell stabilizing effects[1][2].
CAS Number
[147084-10-4]
Product Name Alternative
R89674
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Alcaftadine.html
Purity
98.37
Solubility
DMSO : ≥ 40 mg/mL
Smiles
O=CC1=CN=C2N1CCC3=CC=CC=C3/C2=C4CCN(C)CC\4
Molecular Formula
C19H21N3O
Molecular Weight
307.39
Precautions
H315, H319, H335
References & Citations
[1]Namdar, R. and C. Valdez, Alcaftadine: a topical antihistamine for use in allergic conjunctivitis. Drugs Today (Barc), 2011. 47 (12) : p. 883-90.|[2]Mahvan, T.D., W.A. Buckley, and J.R. Hornecker, Alcaftadine for the prevention of itching associated with allergic conjunctivitis. Ann Pharmacother, 2012. 46 (7-8) : p. 1025-32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H1 Receptor; H2 Receptor

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