Alcaftadine

• Description:

  Alcaftadine (R89674) is a histamine H1 receptor antagonist, which is used to prevent eye irritation brought on by allergic conjunctivitis. Alcaftadine is a broad-spectrum antihistamine displaying a high affinity for histamine H1 and H2 receptors and a lower affinity for H4 receptors. Alcaftadine also exhibits modulatory action on immune cell recruitment and mast cell stabilizing effects[1][2].

• Product Name Alternative:

  R89674

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Histamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/Alcaftadine.html

• Purity:

  98.37

• Solubility:

  DMSO : ≥ 40 mg/mL

• Smiles:

  O=CC1=CN=C2N1CCC3=CC=CC=C3/C2=C4CCN(C)CC\4

• Molecular Formula:

  C19H21N3O

• Molecular Weight:

  307.39

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Namdar, R. and C. Valdez, Alcaftadine: a topical antihistamine for use in allergic conjunctivitis. Drugs Today (Barc), 2011. 47 (12) : p. 883-90.|[2]Mahvan, T.D., W.A. Buckley, and J.R. Hornecker, Alcaftadine for the prevention of itching associated with allergic conjunctivitis. Ann Pharmacother, 2012. 46 (7-8) : p. 1025-32.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  H1 Receptor; H2 Receptor

• CAS Number:

  [147084-10-4]