Alcaftadine

• Description :

  Alcaftadine (R89674) is a histamine H1 receptor antagonist, which is used to prevent eye irritation brought on by allergic conjunctivitis. Alcaftadine is a broad-spectrum antihistamine displaying a high affinity for histamine H1 and H2 receptors and a lower affinity for H4 receptors. Alcaftadine also exhibits modulatory action on immune cell recruitment and mast cell stabilizing effects[1][2].

• Product Name Alternative :

  R89674

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Histamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/Alcaftadine.html

• Purity :

  98.37

• Solubility :

  DMSO : ≥ 40 mg/mL

• Smiles :

  O=CC1=CN=C2N1CCC3=CC=CC=C3/C2=C4CCN(C)CC\4

• Molecular Formula :

  C19H21N3O

• Molecular Weight :

  307.39

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Namdar, R. and C. Valdez, Alcaftadine: a topical antihistamine for use in allergic conjunctivitis. Drugs Today (Barc), 2011. 47 (12) : p. 883-90.|[2]Mahvan, T.D., W.A. Buckley, and J.R. Hornecker, Alcaftadine for the prevention of itching associated with allergic conjunctivitis. Ann Pharmacother, 2012. 46 (7-8) : p. 1025-32.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  H1 Receptor; H2 Receptor

• CAS Number :

  [147084-10-4]