NT376

CAT: 0804-HY-163806Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-163806Size:1 Each

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Description

NT376 is a high potency and selectivity inhibitor of class-IIa Histone deacetylases (HDAC) with an IC50 value of 32 nM, similar to NT160 (IC50= 46 nM) in HT-29 cells. NT376 is proming for research of various cancers and in the diseases of the central nervous system (CNS) such as Alzheimer’s and Huntington’s diseases[1].

CAS Number

2820208-97-5

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nt376.html

Smiles

O=C(N[C@H](C)CN(CC1=CC=CC=C1)C)C2=CC=C(C3=NOC(C(F)(F)F)=N3)C=C2F

Molecular Formula

C21H20F4N4O2

Molecular Weight

436.40

References & Citations

[1]Xu S, et al. Design and radiosynthesis of class-IIa HDAC inhibitor with high molar activity via repositioning the 18F-radiolabel[J]. Sci Rep. 2024 Jul 2;14 (1) :15100.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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GTR19237901-01	NT376

NT376

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