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Recombinant Amyloid Precursor Protein (APP)

CAT: 0338-TRV-038242-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0338-TRV-038242-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9000-83-3
Product Name Alternative
AAA; ABeta; ABPP; AD1; APPI; CVAP; PN2; CTFgamma; Peptidase Nexin-II Alzheimer Disease; Peptidase Nexin-II; Amyloid Beta (A4) Precursor Protein
Synonyms
Amyloid Precursor Protein
UniProt
P05067
Expression System
Prokaryotic expression
Host
E. coli
Tag
Two N-terminal Tags, His-tag and MBP-tag
Source
Prokaryotic expression
Applications
Positive Control; Immunogen; SDS-PAGE; WB.
Field of Research
Neuro science
Endotoxin
<1.0EU per 1μg (determined by the LAL method)
Purity
> 90%
Form
Freeze-dried powder
Buffer
20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Calculated Molecular Weight
54.2kDa
Observed Molecular Weight
54kDa
Fragment
Asp672~Val711
Isoelectric Point
5.5
Subcellular Location
Membrane, Nucleus, Secreted, Cytoplasm
Product Name Synonym
Amyloid Precursor Protein
Host or Source
E.coli
Organism Species
Homo sapiens (Human)

UniProtKB · P05067

Amyloid-beta precursor protein

A4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P05067
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
APP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
APP
EC number
—
Processing
Precursor
Secondary accessions
B2R5V1, B4DII8, D3DSD1, D3DSD2, D3DSD3, P09000, P78438, Q13764, Q13778, Q13793, Q16011, Q16014, Q16019, Q16020, Q6GSC0, Q8WZ99, Q9BT38, Q9UC33, Q9UCA9, Q9UCB6, Q9UCC8, Q9UCD1, Q9UQ58
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Alzheimer diseaseAmyloidosisDisease variantNeurodegeneration

Cellular component

AmyloidCell membraneCell projectionCoated pitCytoplasmCytoplasmic vesicleEndoplasmic reticulumEndosomeGolgi apparatusMembraneNucleusSecreted

Biological process

ApoptosisCell adhesionEndocytosisNotch signaling pathway

Ligand

CopperIronMetal-bindingZinc

PTM

Disulfide bondGlycoproteinIsopeptide bondOxidationPhosphoproteinProteoglycanSulfationUbl conjugation

Molecular function

Heparin-bindingProtease inhibitorSerine protease inhibitor

Domain

SignalTransmembraneTransmembrane helix

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