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Adrenosterone

CAT: 0804-HY-17462-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17462-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Adrenosterone ((+) -Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells[1][2][3].
CAS Number
382-45-6
Product Name Alternative
(+) -Adrenosterone
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Androgen Receptor; Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/adrenosterone.html
Concentration
10mM
Purity
98.97
Solubility
DMSO : 31.25 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
C[C@@]([C@](CC1)([H])[C@]2([H])CCC3=CC(CC[C@]3(C)[C@@]2([H])C4=O)=O)(C4)C1=O
Molecular Formula
C19H24O3
Molecular Weight
300.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Brooker L, et al. Carbon isotope ratio analysis of endogenous glucocorticoid urinary metabolites after cortisone acetate andadrenosterone administration for doping control. Drug Test Anal. 2012 Dec;4 (12) :951-61.|[2]Choudhary MI, et al. Biotransformation of adrenosterone by filamentous fungus, Cunninghamella elegans. Steroids. 2007 Dec;72 (14) :923-9.|[3]Joji Nakayama, et al. A Novel Zebrafish Model of Metastasis Identifies the HSD11β1 Inhibitor Adrenosterone as a Suppressor of Epithelial-Mesenchymal Transition and Metastatic Dissemination. Mol Cancer Res. 2020 Mar;18 (3) :477-487.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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