Human Casein Kinase I Isoform Alpha (CSNK1A1)

• Description:

  Human Casein Kinase I Isoform Alpha (CSNK1A1)_x000D_ Catalog number: B2012399_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 20 ug_x000D_ Molecular Weight or Concentration: 41 kDa_x000D_ Supplied as: Solution_x000D_ Applications: molecular tool for various biochemical applications_x000D_ Storage: -20°C_x000D_ Keywords: CKI-alpha, CK1, CSNK1A1, HLCDGP1_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Liu G, Li H, Zhang W, Yu J, Zhang X, Wu R, Niu M, Liu X, Yu R. Csnk1a1 inhibition modulates the inflammatory secretome and enhances response to radiotherapy in glioma J Cell Mol Med. 2021 Aug;25(15):7395-7406._x000D_ 2: Hosono N. Genetic abnormalities and pathophysiology of MDS Int J Clin Oncol. 2019 Aug;24(8):885-892._x000D_ 3: Sauta E, Reggiani F, Torricelli F, Zanetti E, Tagliavini E, Santandrea G, Gobbi G, Strocchi S, Paci M, Damia G, Bellazzi R, Ambrosetti D, Ciarrocchi A, Sancisi V. CSNK1A1, KDM2A, and LTB4R2 Are New Druggable Vulnerabilities in Lung Cancer Cancers (Basel). 2021 Jul 12;13(14):3477._x000D_ 4: Niu T, De Rosny C, Chautard S, Rey A, Patoli D, Groslambert M, Cosson C, Lagrange B, Zhang Z, Visvikis O, Hacot S, Hologne M, Walker O, Wong J, Wang P, Ricci R, Henry T, Boyer L, Petrilli V, Py BF. NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly Nat Commun. 2021 Oct 6;12(1):5862._x000D_ 5: Kadosh E, Snir-Alkalay I, Venkatachalam A, May S, Lasry A, Elyada E, Zinger A, Shaham M, Vaalani G, Mernberger M, Stiewe T, Pikarsky E, Oren M, Ben-Neriah Y. The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic Nature. 2020 Oct;586(7827):133-138._x000D_ 6: Ribezzo F, Snoeren IAM, Ziegler S, Stoelben J, Olofsen PA, Henic A, Ferreira MV, Chen S, Stalmann USA, Buesche G, Hoogenboezem RM, Kramann R, Platzbecker U, Raaijmakers MHGP, Ebert BL, Schneider RK. Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome Leukemia. 2019 Jul;33(7):1759-1772._x000D_ 7: Stegmaier K. Targeting Csnk1a1 in leukemia J Exp Med. 2014 Apr 7;211(4):594._x000D_ 8: Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, Ishii R, Muto S, Kotani S, Watatani Y, Takeda J, Sanada M, Tanaka H, Suzuki H, Sato Y, Shiozawa Y, Yoshizato T, Yoshida K, Makishima H, Iwanaga M, Ma G, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Ogasawara H, Sato T, Sasai K, Muramoto K, Penova M, Kawaguchi T, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Nakamaki T, Ishiyama K, Miyawaki S, Yoon SS, Tobinai K, Miyazaki Y, Takaori-Kondo A, Matsuda F, Takeuchi K, Nureki O, Aburatani H, Watanabe T, Shibata T, Matsuoka M, Miyano S, Shimoda K, Ogawa S. Integrated molecular analysis of adult T cell leukemia/lymphoma Nat Genet. 2015 Nov;47(11):1304-15._x000D_ 9: Feng X, Jia Y, Zhang Y, Ma F, Zhu Y, Hong X, Zhou Q, He R, Zhang H, Jin J, Piao D, Huang H, Li Q, Qiu X, Zhang Z. Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth Autophagy. 2019 Jul;15(7):1130-1149._x000D_ 10: JärÃ¥s M, Miller PG, Chu LP, Puram RV, Fink EC, Schneider RK, Al-Shahrour F, Peña P, Breyfogle LJ, Hartwell KA, McConkey ME, Cowley GS, Root DE, Kharas MG, Mullally A, Ebert BL. Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia J Exp Med. 2014 Apr 7;211(4):605-12. _x000D_ _x000D_ Products Related to Human Casein Kinase I Isoform Alpha (CSNK1A1) can be found at Enzymes

• Short Description:

  Catalog Number: B2012399 (20 ug)_x000D_ Human Casein Kinase I Isoform Alpha (CSNK1A1) is a high quality Human Casein Kinase I Isoform Alpha expressed in E. coli. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5