Donepezil

CAT: 1596-AR-Z00955-06Size: 250 UnitsDry Ice: NoHazardous: No

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CAT#:1596-AR-Z00955-06Size:250 Units

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CAS Number

120014-06-4

Synonyms

2- ((1-benzylpiperidin-4-yl) methyl) -5,6-dimethoxy-2,3-dihydro-1H-inden-1-one; 2,3-Dihydro-5,6-dimethoxy-2-[[1- (phenylmethyl) -4-piperidinyl]methyl]-1H-inden-1-one; (±) -E 2020; 1-Benzyl-4-[ (5,6-dimethoxy-1-oxoindan-2-yl) methyl]piperidine; Donepezil; Neuripezil; Tonizep

Molecular Formula

C24H29NO3

Molecular Weight

379.5

API Name

Donepezil

Chemical Information

Donepezil

Donepezil is a racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor, an EC 3.1.1.7 (acetylcholinesterase) inhibitor and a nootropic agent. It contains a (S)-donepezil and a (R)-donepezil. It is a conjugate base of a donepezil (1+).

CAS Number	120014-06-4
PubChem CID	3152
IUPAC Name	2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
Molecular Formula	C24H29NO3
Molecular Weight	379.5
XLogP	4.3
Topological Polar Surface Area	38.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Heavy Atom Count	28
Formal Charge	0
Complexity	510

SMILES

COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC

InChI

InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3

InChIKey

ADEBPBSSDYVVLD-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 120014-06-4

CID: 3152

Formula: C24H29NO3

MW: 379.5

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	379.5
XLogP3	4.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	379.21474379
Monoisotopic Mass	379.21474379
Topological Polar Surface Area	38.8 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	510
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
AR-D07508-01	DonepezilÂ Quaternary salt (Donepezilbenzyl) (USP)

Alternative Products

Catalog	Name
TRC-D229535-25MG	Dehydrodeoxy Donepezil (Donepezil Impurity)
sc-218104	Dehydro Donepezil (Donepezil Impurity)
BA8451-50	Donepezil
447654	(-) -Donepezil
574677	(+)-Donepezil
GTR19209160-01	(+) -Donepezil

Donepezil

Chemical Information

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