ML-290

• Description :

  ML-290 is a first-in-class and potent relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes, with an EC50 of 94 nM[1]. ML290 is a biased allosteric agonist at the relaxin receptor RXFP1.

• UNSPSC :

  12352005

• Target :

  RXFP Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/ML-290.html

• Purity :

  99.81

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1=CC(S(=O)(C(F)(F)F)=O)=CC=C1)C2=C(NC(C3=CC=CC=C3OC(C)C)=O)C=CC=C2

• Molecular Formula :

  C24H21F3N2O5S

• Molecular Weight :

  506.49

• References & Citations :

  [1]Wilson KJ, et al. Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile. Eur J Med Chem. 2018 Aug 5;156:79-92.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1482500-76-4]