Telaprevir

• Description:

  Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (Ki) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide[1][2][3]. Telaprevir inhibits SARS-CoV-2 3CLpro activity[4].

• Product Name Alternative:

  VX-950

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  HCV; HCV Protease; SARS-CoV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/Telaprevir.html

• Purity:

  99.77

• Solubility:

  DMSO : ≥ 50 mg/mL

• Smiles:

  O=C (N ([C@@H]1C (N[C@H] (C (C (NC2CC2) =O) =O) CCC) =O) C[C@@]3 (CCC[C@@]31[H]) [H]) [C@@H] (NC ([C@@H] (NC (C4=NC=CN=C4) =O) C5CCCCC5) =O) C (C) (C) C

• Molecular Formula:

  C36H53N7O6

• Molecular Weight:

  679.85

• Precautions:

  H302

• References & Citations:

  [1]Lin K, et al. VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCv replicon cells. Antimicrob Agents Chemother. 2006 May;50 (5) :1813-22.|[2]Perni RB, et al. Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease. Antimicrob Agents Chemother. 2006 Mar;50 (3) :899-909.|[3]Zhang X, et al. Discovery and evolution of aloperine derivatives as a new family of HCV inhibitors with novel mechanism. Eur J Med Chem. 2018 Jan 1;143:1053-1065.|[4]Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6 (1) :212.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  402957-28-2