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Durvalumab ELISA Kit

CAT: 1358-DV974038Size: 96 TestsDry Ice: NoHazardous: No
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CAT#:1358-DV974038Size:96 Tests
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Durvalumab (dur val" ue mab) is a human recombinant monoclonal IgG1 kappa-isotype antibody to the ligand for programmed cell death receptor-1 (PD-L1) which leads to enhanced T cell responses against cancer cells and is used in cancer immunotherapy. PD-1 is an important checkpoint molecule that modulates and down regulates T cell responses. Inhibition of the PD-L1 prevents its binding to the programmed cell death receptor 1 which is responsible for down regulating T cell responses. Inhibition of this pathway allows for a continued activation and proliferation of T cells. The subsequent enhancement of cytotoxic reactivity may play a beneficial role in cancer immunotherapy by breaking immunological tolerance to cancer cell neo-antigens. In several large multicenter studies, durvalumab therapy resulted in a prolongation of survival in patients with advanced, metastatic or unresectable urothelial carcinoma, and a proportion of patients had a long term remission.
Specifications
Durvalumab
Product Name Alternative
MEDI4736, CAS: 1428935-60-7
Detection Method
Colorimetric
Assay Type
Quantitative
Sample Type
Plasma, Serum
Detection Range
0.31-5 μg/mL
Recovery
80-120%
Sensitivity
0.156 μg/ml
Shipping Conditions
2-8 °C
Storage Conditions
The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.
Notes
For Research Use Only.

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