RegisterLogin

Bimagrumab ELISA Kit

CAT: 1358-DB949018Size: 96 TestsDry Ice: NoHazardous: No
CAT#:1358-DB949018Size:96 Tests
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Bimagrumab is a monoclonal anti-ActRIIA/IIB antibody that targets ActRIIA and ActRIIB simultaneously. Native ActRIIA and ActRIIB are both mediators of signaling from several TGFβ superfamily members such as activins, myostatin, and GDF11. Hence, pan-blockade by Bimagrumab achieves greater effect than a monoclonal antibody against either receptor alone, i.e. monotherapy with anti-ActRIIA antibody or anti-ActRIIB antibody. Bimagrumab has been explored as a therapy for sporadic inclusion body myositis, primary sarcopenia, and muscle wasting associated with chronic obstructive pulmonary disease.
Description
PRINCIPLE OF THE ASSAY This assay employs the quantitative competitive enzyme immunoassay technique. Recombinant Human ACVR2A has been pre-coated onto a microplate. Standards or samples are premixed with biotin-labeled antibody and then pipetted into the wells. Bimagrumab in the sample competitively binds to the pre-coated protein with biotin-labeled Bimagrumab. After washing away any unbound substances, Streptavidin-HRP is added to the wells. Following a wash to remove any unbound enzyme reagent, a substrate solution is added to the wells and color develops in inversely proportion to the amount of Bimagrumab bound in the initial step. The color development is stopped and the intensity of the color is measured.
Specifications
Bimagrumab
Product Name Alternative
BYM338, CAS: 1356922-05-8
Detection Method
Colorimetric
Assay Type
Quantitative
Sample Type
Plasma, Serum
Detection Range
125 - 4,000 ng/mL
Recovery
80-120%
Sensitivity
97.28 ng/mL
Shipping Conditions
2-8 °C
Storage Conditions
When the kit was stored at the recommended temperature for 6 months, the signal intensity decreased by less than 20%. For unopened kits, if you want to prolong the storage time, please store the Standard, Detection A, Detection B and Microplate at - 20 °C, the rest reagents should be store at 4°C.
Notes
For Research Use Only.

Related Products

CatalogName
HB949016-01Research Grade Bimagrumab
DF004048Panitumumab ELISA Kit
DF879028Certolizumab ELISA Kit
DF879038Golimumab ELISA Kit
DF996018Basiliximab ELISA Kit
DF996028Camidanlumab ELISA Kit
DY524018Eldelumab ELISA Kit
DY328018Clazakizumab ELISA Kit
DY328028Olokizumab ELISA Kit
DY328048Ziltivekimab ELISA Kit

Alternative Products

CatalogName
KBI1192KRIBIOLISA™ Bimagrumab ELISA
KET-10724Bimagrumab ELISA Kit
M36745-01Bimagrumab
E55B0616Bimagrumab (Reference antibody)
DHD72801Research Grade Bimagrumab
C00381-01Bimagrumab (Anti-ACVR2B)
047624ACVR2B (bimagrumab) discontinued
591712Bimagrumab (ACVR2A, ACVR2B)
ICH5402-20mgBimagrumab Biosimilar - Research Grade
ABS-260-100ugBimagrumab Biosimilar, Research Grade

Popular Products