5-Carboxy-2′-deoxyuridine

5-Carboxy-2′-deoxyuridine

• CAS Number: 14599-46-3
• UNSPSC Description: 5-Carboxy-2′-deoxyuridine is a metabolite of Trifluridine[1]. 5-Carboxy-2′-deoxyuridine is a methyl oxidation product of Thymidine that can be formed by menadione-mediated photosensitization of Thymidine[2].
• Target Antigen: Drug Metabolite
• Type: Enzyme
• Related Pathways: Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/5-carboxy-2-deoxyuridine.html
• Purity: 98.98
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: O[C@H]1C[C@H](N2C(NC(C(C(O)=O)=C2)=O)=O)O[C@@H]1CO
• Molecular Weight: 272.21
• References & Citations: [1]V Guerniou, et al. New synthesis of 5-carboxy-2'-deoxyuridine and its incorporation into synthetic oligonucleotides. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1073-5.|[2]D Pavan-Langston, et al. Intraocular penetration of trifluridine. Am J Ophthalmol. 1979 Jun;87(6):814-8.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported