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DY131

CAT: 0804-HY-15483-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15483-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DY131 (GSK 9089) is a potent and selective ERRγ and ERRβ agonist. DY131displays inactive against ERRα, ERα and ERβ[1][2]. DY131 also inhibits Smo signaling[3].
CAS Number
95167-41-2
Product Name Alternative
GSK 9089
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Estrogen Receptor/ERR; Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/DY131.html
Concentration
10mM
Purity
99.72
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N/N=C/C1=CC=C(N(CC)CC)C=C1)C2=CC=C(O)C=C2
Molecular Formula
C18H21N3O2
Molecular Weight
311.38
Precautions
H302, H312, H332
References & Citations
[1]Wang Y, et al. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation . ACS Chem Biol. 2012,15;7 (6) :1040-8.|[2]Yamamoto T, et al. Estrogen-related receptor-γ regulates estrogen receptor-α responsiveness in uterine endometrial cancer. Int J Gynecol Cancer. 2012;22 (9) :1509-16.|[3]Yu S, et al. ERRgamma suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer. Cancer Res. 2007;67 (10) :4904-14.|[4]Donna D. Yu, Barry Marc Forman. Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorganic & Medicinal Chemistry Letters. 2005,15 (5) : 1311-1313.|[5]A Pacwa, et al. Interplay between estrogen-related receptors and steroidogenesis-controlling molecules in adrenals. In vivo and in vitro study. Acta Histochem. 2018 Jul;120 (5) :456-467.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERRβ; ERRγ

Alternative Products

CatalogName
A3375-25DY131
A15071-200DY131 200mg
A15071-10DY131 10mg
A15071-50DY131 50mg
A15071-100DY131 100mg
A15071-25DY131 25mg
A15071-5DY131 5mg

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