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SUVN-911

CAT: 0804-HY-136146-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136146-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a Ki of 1.5 nM. SUVN-911 has antidepressant activity[1].
CAS Number
2414674-71-6
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/suvn-911.html
Concentration
10mM
Purity
99.40
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
ClC1=NC=C(OC[C@H]2N[C@@H]3C[C@@H]3C2)C=C1.[H]Cl
Molecular Formula
C11H14Cl2N2O
Molecular Weight
261.15
References & Citations
[1]Ramakrishna Nirogi, et al. Discovery and Development of 3- (6-Chloropyridine-3-yloxymethyl) -2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911) : A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression. J Med Chem. 2020 Mar 26;63 (6) :2833-2853.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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