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Research Grade MEDI3185

CAT: 1358-HX206026-01Size: 100 µgDry Ice: NoHazardous: No
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CAT#:1358-HX206026-01Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MEDI3185haspicomolarbindingaffinitytohumanCXCR4andexhibitsnosignificantbindingtootherchemokinereceptorssuchasCCR4orCXCR3.InvitrostudiesdemonstratedthatMEDI3185inhibitedtumorcellmigration, blockedSDF-1inducedtumorcellsignalingandinducedapoptosisoftumorcells.TheMEDI3185epitopecomprisestheentireECL2sequence, lacksanyso-called'hot-spot'andisremarkablyresistanttomutations.ThestructureofMEDI3185variabledomainswasmodeled, andsuggestedaβ-strand/β-strandinteractionbetweenMEDI3185CDR3HandCXCR4ECL2, resultingindirectsterichindrancewithCXCR4ligandSDF-1.
Expression System
Mammalian Cells
Host
Human
Target
Stromalcell-derivedfactor1receptor, LCR1, HM89, LPS-associatedprotein3, LAP-3, CXC-R4, CXCR-4, SDF-1receptor, CD184, NPYRL, LESTR, Fusin, FB22, C-X-Cchemokinereceptortype4, CXCR4, Lipopolysaccharide-associatedprotein3, Leukocyte-derivedseventransmembranedomainreceptor
Clonality
Monoclonal
Applications
ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Purification
Protein A/G purified from cell culture supernatant.
Concentration
1mg/ml
Endotoxin
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Form
Liquid
Buffer
0.01M PBS, pH7.4.
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at4°C short term (1-2weeks) . Store at-20°C 12 months. Store at -820°C long term.
Notes
For research use only. Not suitable for clinical or therapeutic use.
Buffer pH
0.01M PBS, pH7.4.
Species
Human
Isotype
IgG1

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