Products for Research Use Only
RegisterLogin

Edicotinib

CAT: 0804-HY-109086-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-109086-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active colony-stimulating factor-1 receptor (CSF-1R) inhibitor with an IC50 of 3.2 nM. Edicotinib exhibits less inhibitory effects on KIT and FLT3 with IC50 values of 20 nM and 190 nM, respectively[1]. Edicotinib limits microglial expansion and attenuates microglial proliferation and neurodegeneration in mice. Edicotinib has the potential for Alzheimer’s disease and rheumatoid arthritis research[1][2].
CAS Number
1142363-52-7
Product Name Alternative
JNJ-40346527; JNJ-527
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
C-Fms
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Edicotinib.html
Purity
99.68
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
O=C(C1=NC=C(C#N)N1)NC2=C(C3=CCC(C)(C)CC3)N=C(C(CC(C)(C)O4)CC4(C)C)C=C2
Molecular Formula
C27H35N5O2
Molecular Weight
461.60
Precautions
H302, H315, H319, H335
References & Citations
[1]Mancuso R, et al. CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.Brain. 2019 Oct 1;142 (10) :3243-3264.|[2]Genovese MC, et al. Results from a Phase IIA Parallel Group Study of JNJ-40346527, an Oral CSF-1R Inhibitor, in Patients with Active Rheumatoid Arthritis despite Disease-modifying Antirheumatic Drug Therapy.J Rheumatol. 2015 Oct;42 (10) :1752-60.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
BA8848-10Edicotinib
A13008-1Edicotinib 1mg
A13008-5Edicotinib 5mg
MBS5812985Edicotinib HCl
A13008-100Edicotinib 100mg
A13008-2Edicotinib 2mg
A13008-50Edicotinib 50mg
A13008-25Edicotinib 25mg
A13008-10Edicotinib 10mg
C13468-01Edicotinib (JNJ-40346527)

Popular Products