Phyllanthin

• UNSPSC Description:

  Phyllanthin is an effective oral anticancer agent. Phyllanthin inhibits MOLT-4 cell viability, increases apoptosis, inhibits cell migration and invasion. Phyllanthin exerts anti-fibrotic effects by down-regulating TGF signaling pathway via ALK5 and Smad2/3. Phyllanthin also has anti-inflammatory and antibacterial properties [1] [2] [3].

• Target Antigen:

  TGF-beta/Smad

• Type:

  Natural Products

• Related Pathways:

  Stem Cell/Wnt;TGF-beta/Smad

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/phyllanthin.html

• Purity:

  99.96

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  COC[C@@H](CC1=CC=C(OC)C(OC)=C1)[C@@H](COC)CC2=CC=C(OC)C(OC)=C2

• Molecular Weight:

  418.52

• References & Citations:

  [1]Hassanein EHM, et al. The promising antioxidant effects of lignans: Nrf2 activation comes into view. Naunyn Schmiedebergs Arch Pharmacol. 2024 Sep;397(9):6439-6458. |[2]Krithika R, et al. Mechanism of protective effect of phyllanthin against carbon tetrachloride-induced hepatotoxicity and experimental liver fibrosis in mice. Toxicol Mech Methods. 2015;25(9):708-17.|[3]Wang H, et al. Phyllanthin inhibits MOLT-4 leukemic cancer cell growth and induces apoptosis through the inhibition of AKT and JNK signaling pathway. J Biochem Mol Toxicol. 2021 Jun;35(6):1-10. |[4]Harikrishnan H, et al. Phyllanthin from Phyllanthus amarus inhibits LPS-induced proinflammatory responses in U937 macrophages via downregulation of NF-κB/MAPK/PI3K-Akt signaling pathways. Phytother Res. 2018 Dec;32(12):2510-2519.|[5]You Y, et al. Phyllanthin prevents diethylnitrosamine (DEN) induced liver carcinogenesis in rats and induces apoptotic cell death in HepG2 cells. Biomed Pharmacother. 2021 May;137:111335.|[6]Ilangkovan M, et al. Phyllanthin from Phyllanthus amarus inhibits cellular and humoral immune responses in Balb/C mice. Phytomedicine. 2016 Nov 15;23(12):1441-1450.|[7]Marhaeny HD, et al. Phyllanthin and hypophyllanthin, the isolated compounds of Phyllanthus niruri inhibit protein receptor of corona virus (COVID-19) through in silico approach. J Basic Clin Physiol Pharmacol. 2021 Jun 25;32(4):809-815.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  10351-88-9