Recombinant Human DEFβ2/DEFB2 protein (GST tag)

• Background:

  Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells.

• Abbreviation:

  DEFβ2; DEFB2

• Synonyms:

  BD-2; Beta-defensin 2; Defensin; SAP1; Skin-antimicrobial peptide 1; beta 2; hBD-2

• UniProt:

  O15263

• Accession Number:

  O15263

• Expression System:

  E.coli

• Tag:

  N-GST

• Sequence:

  Gly24-Pro64

• Field of Research:

  Microbiology

• Endotoxin:

  < 10 EU/mg of the protein as determined by the LAL method.

• Purity:

  > 85% as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  30.3 kDa

• Observed Molecular Weight:

  33 kDa

• Species:

  Human