Recombinant Human BMPR2 protein (His tag)

• Background:

  On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.

• Abbreviation:

  BMPR2

• Synonyms:

  BMP type II receptor; BMP type-2 receptor; BMPR-2; BMPR-II; Bone morphogenetic protein receptor type II

• UniProt:

  Q13873

• Accession Number:

  Q13873

• Expression System:

  E.coli

• Tag:

  N-His

• Sequence:

  Ser27-Thr150

• Field of Research:

  Signal Transduction, Stem Cells, Cardiovascular

• Endotoxin:

  < 10 EU/mg of the protein as determined by the LAL method.

• Purity:

  > 85% as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  26 kDa

• Observed Molecular Weight:

  35 kDa

• Species:

  Human