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Afatinib dimaleate

CAT: 0026-B3072-250Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0026-B3072-250Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Afatinib is an irreversible dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) tyrosine kinase. It shows IC₅₀ values of 0.5 nM and 14 nM for EGFR kinase and HER2 kinase respectively. It inhibits EGF-induced EGFR phosphorylation and cellular proliferation in cell lines such as EGFR-overexpressing and HER2-expressing cell lines A431, NIH-3T3-HER2, NCI-N87 and BT-474. It causes tumour regression in mice carrying EGFR-overexpressing and HER2-expressing A431 xenografts, EGFR-overexpressing and HER2-expressing MDA-MB-453 xenografts and NCI-N87 gastric and SKOV-3 ovarian models.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

Alternative Products

CatalogName
HY-10261A-01Afatinib (dimaleate)
6812/50Afatinib dimaleate

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