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Succinylsulfathiazole

CAT: 0804-HY-B0921-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-B0921-01Size:1 g
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Description
Succinylsulfathiazole (Succinylsulphathiazole) is a long-acting sulfonamide antibiotic. Succinylsulfathiazole works by inhibiting bacterial folate synthesis through competitive inhibition with P-aminobenzoic acid (PABA) . Succinylsulfathiazole is a gut antiseptic to lower the bacterial load and prevent infections after gut surgeries. Succinylsulfathiazole can produce large shifts in the composition of the gut flora and the ability to synthetize folate[1][2].
CAS Number
116-43-8
Product Name Alternative
Succinylsulphathiazole
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Succinylsulfathiazole.html
Purity
99.22
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(O)CCC(NC1=CC=C(S(=O)(NC2=NC=CS2)=O)C=C1)=O
Molecular Formula
C13H13N3O5S2
Molecular Weight
355.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Sepehr E, et al. Folate derived from cecal bacterial fermentation does not increase liver folate stores in 28-d folate-depleted male Sprague-Dawley rats. J Nutr. 2003 May;133 (5) :1347-54.|[2]Beydoun S, et al. Succinylsulfathiazole modulates the mTOR signaling pathway in the liver of c57BL/6 mice via a folate independent mechanism. Exp Gerontol. 2021 Jul 15;150:111387.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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CatalogName
C6685-100Succinylsulfathiazole

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