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LAS17

CAT: 0804-HY-115673-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-115673-01Size:5 mg
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Description
LAS17 is a potent and selective tyrosine-directed irreversible inhibitor for glutathione S-Transferase Pi (GSTP1) [1]. LAS17 inhibits GSTP1 activity with an IC50 of 0.5 μM[2]. LAS17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
2362527-67-9
Product Name Alternative
d,l-SKF89976A hydrochloride, E64d; E64c ethyl ester
UNSPSC
12352005
Target
Glutathione S-transferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/las17.html
Purity
97.46
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)C[C@H](C(OC)=O)N(C1=NC(Cl)=NC(Cl)=N1)CCCC#C
Molecular Formula
C15H20Cl2N4O2
Molecular Weight
359.25
References & Citations
[1]L A Crawford, et al. A tyrosine-reactive irreversible inhibitor for glutathione S-transferase Pi (GSTP1) . Mol Biosyst. 2016 May 24;12 (6) :1768-71.|[2]Sharon M Louie, et al. GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity. Cell Chem Biol. 2016 May 19;23 (5) :567-578.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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