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Nexinhib20

CAT: 0804-HY-125792-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-125792-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nexinhib20 is an inhibitor that targets the interactions of Rab27a-JFC1 (IC50: 2.6 μM) and Rac-1-GTP. Nexinhib20 can inhibit neutrophil exocytosis, adhesion, and β2 integrin activation, and has anti-inflammatory activity. Nexinhib20 can be used in the research of diseases such as systemic inflammation and myocardial ischemia-reperfusion injury[1][2].
CAS Number
331949-35-0
UNSPSC
12352005
Target
Integrin; Ras; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Cytoskeleton; GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nexinhib20.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(/C(N1N=CN=C1)=C/C2=CC=CC([N+]([O-])=O)=C2)C(C)(C)C
Molecular Formula
C15H16N4O3
Molecular Weight
300.31
References & Citations
[1]Johnson JL, et al. Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a. J Biol Chem. 2016 Dec 9;291 (50) :25965-25982.|[2]Liu W, et al. Nexinhib20 Inhibits Neutrophil Adhesion and β2 Integrin Activation by Antagonizing Rac-1-Guanosine 5'-Triphosphate Interaction. J Immunol. 2022 Oct 15;209 (8) :1574-1585.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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