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Protohypericin

CAT: 0804-HY-N4139-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N4139-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Protohypericin is a compound that can be extracted from Hypericum perforatum. Protohypericin has low photocytotoxicity but can be efficiently photoconverted into Hypericin with high phototoxicity under visible light. Protohypericin can be used in cancer research[1][2][3][4].
CAS Number
548-03-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Drug Intermediate
Type
Natural Products
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protohypericin.html
Purity
95.15
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(C1=C(O)C=C(C)C=C1C2=C34)C3=C(O)C=C(O)C4=C5C(O)=CC(O)=C6C(C7=C(O)C=C(C)C=C7C2=C65)=O
Molecular Formula
C30H18O8
Molecular Weight
506.46
Precautions
H302, H315, H319
References & Citations
[1]Baugh SF. Simultaneous determination of protopseudohypericin, pseudohypericin, protohypericin, and hypericin without light exposure. J AOAC Int. 2005 Nov-Dec;88 (6) :1607-12.|[2]Liu X, et al. Tumor necrosis targeted radiotherapy of non-small cell lung cancer using radioiodinated protohypericin in a mouse model. Oncotarget. 2015 Sep 22;6 (28) :26400-10.|[3]Kamuhabwa AR, et al. In vitro transport and uptake of protohypericin and hypericin in the Caco-2 model. Int J Pharm. 1999 Oct 15;188 (1) :81-6.|[4]Delaey EM, et al. Photocytotoxicity of protohypericin after photoconversion to hypericin. Planta Med. 1999 Dec;65 (8) :719-22.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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