Doxylamine

• UNSPSC Description:

  Doxylamine, a first generation antihistamine, is a histamine (H1) receptor antagonist. Doxylamine is also a local analgesic agent and effective hypnotic agent[1][2][3].

• Target Antigen:

  Histamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/doxylamine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C1=NC=CC=C1)(C2=CC=CC=C2)OCCN(C)C

• Molecular Weight:

  270.37

• References & Citations:

  [1]Sjöqvist F, Lasagna L. The hypnotic efficacy of doxylamine. Clin Pharmacol Ther. 1967;8(1):48-54.|[2]Hung CH, et al. Subcutaneous infiltration of doxylamine on cutaneous analgesia in rats. Pharmacol Rep. 2018;70(3):565-569.|[3]Jackson CD, Blackwell BN. Subchronic studies of doxylamine in B6C3F1 mice. Fundam Appl Toxicol. 1988;10(2):254-261.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  469-21-6