OAC1

• Description :

  OAC1 is a potent Oct4 activator. OAC1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. OAC1 activates OCT4 through upregulation of HOXB4 expression. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and TET1. OAC1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Oct3/4; TET Protein

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; Stem Cell/Wnt

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/OAC1.html

• Purity :

  99.85

• Solubility :

  DMSO : ≥ 40 mg/mL

• Smiles :

  O=C(NC1=CC2=C(NC=C2)C=N1)C3=CC=CC=C3

• Molecular Formula :

  C14H11N3O

• Molecular Weight :

  237.26

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Li W, et, al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A. 2012 Dec 18;109 (51) :20853-8.|[2]Huang X, et, al. Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression. Leukemia. 2016 Jan;30 (1) :144-53.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TET1

• CAS Number :

  [300586-90-7]