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OAC1

CAT: 0804-HY-12303-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12303-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OAC1 is a potent Oct4 activator. OAC1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. OAC1 activates OCT4 through upregulation of HOXB4 expression. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and TET1. OAC1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time[1][2].
CAS Number
300586-90-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Oct3/4; TET Protein
Type
Reference compound
Related Pathways
Epigenetics; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/OAC1.html
Purity
99.85
Solubility
DMSO : ≥ 40 mg/mL
Smiles
O=C(NC1=CC2=C(NC=C2)C=N1)C3=CC=CC=C3
Molecular Formula
C14H11N3O
Molecular Weight
237.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Li W, et, al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A. 2012 Dec 18;109 (51) :20853-8.|[2]Huang X, et, al. Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression. Leukemia. 2016 Jan;30 (1) :144-53.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TET1

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