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F16

CAT: 0804-HY-100395-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100395-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
F16 is a potent growth inhibitor of the neu-overexpressing cells and also selectively inhibits proliferation of mammary epithelial as well as a variety of mouse mammary tumor and human breast cancer cell lines. F16 is a mitochondriotoxic compound, and triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell[1][2].
CAS Number
36098-33-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/F16.html
Purity
99.94
Solubility
DMSO : ≥ 31 mg/mL|Ethanol : 1 mg/mL (ultrasonic)
Smiles
C[N+]1=CC=C(/C=C/C2=CNC3=C2C=CC=C3)C=C1.[I-]
Molecular Formula
C16H15IN2
Molecular Weight
362.21
Precautions
H302, H315, H319
References & Citations
[1]Fantin VR et al. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell. 2002 Jul;2 (1) :29-42.|[2]Fantin VR et al. F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer Res. 2004 Jan 1;64 (1) :329-36.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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