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SIJ1777

CAT: 0804-HY-164400Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164400Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SIJ1777 is a GNF-7 derivative, possesses potent anti-cancer effects on melanoma cells harboring BRAF class I/II/III mutations. SIJ1777 substantially inhibits the activation of MEK, ERK, and AKT. SIJ1777 remarkably induces apoptosis and significantly blocks migration, invasion, and anchorage-independent growth of melanoma cells harboring BRAF class I/II/II mutations[1].
CAS Number
839707-55-0
UNSPSC
12352005
Target
Akt; Apoptosis; ERK; MEK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sij1777.html
Smiles
O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=NN(C)C=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5
Molecular Formula
C26H23F3N8O2
Molecular Weight
536.51
References & Citations
[1]Kim N, et al. Novel and Potent Small Molecules against Melanoma Harboring BRAF Class I/II/III Mutants for Overcoming Drug Resistance. Int J Mol Sci. 2021 Apr 6;22 (7) :3783.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T200137-01SIJ1777

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