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Mogroside III

CAT: 0804-HY-N0500-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0500-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mogroside III is a triterpenoid glycoside. Mogroside III exhibits maltase inhibitory effect with an IC50 value of 1.6 mM. Mogroside III enhances oocyte developmental potential by promoting autophagy in cumulus cells. Mogroside III, as the active ingredient of the low-polarity glycoside component (L-SGgly), L-SGgly can increase serum GLP-1 levels, improve insulin resistance, and reduce IL-6 levels, and has hypoglycemic, lipid-regulating and anti-inflammatory effects. Mogroside III can be used for the studies of type 2 diabetes mellitus (T2DM) and assisted reproductive technology[1][2][3].
CAS Number
130567-83-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Glycosidase
Type
Natural Products
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/mogroside-iii.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
C[C@@]([C@@](CC[C@H](O[C@]([C@@H]([C@@H](O)[C@@H]1O)O)([H])O[C@@H]1CO)C2(C)C)([H])C2=CC3)([C@@H](C[C@@]45C)O)[C@]3([H])[C@@]4(CC[C@]5([H])[C@H](C)CC[C@H](C(C)(O)C)O[C@@H]([C@@H]([C@@H](O)[C@@H]6O)O)O[C@@H]6CO[C@@H]([C@@H]([C@@H](O)[C@@H]7O)O)O[C@@H]7CO)C
Molecular Formula
C48H82O19
Molecular Weight
963.15
Precautions
H302, H315, H319, H335
References & Citations
[1]Tian X, et al. Mogroside III improves bovine oocyte in vitro maturation by regulating autophagy in cumulus cells. Theriogenology. 2025 Apr 15;237:1-12. |[2]Zhang Y, et al. Anti-hyperglycemic and anti-hyperlipidemic effects of a special fraction of Luohanguo extract on obese T2DM rats. J Ethnopharmacol. 2020 Jan 30;247:112273.|[3]Suzuki YA, et al. Triterpene glycosides of Siraitia grosvenori inhibit rat intestinal maltase and suppress the rise in blood glucose level after a single oral administration of maltose in rats. J Agric Food Chem. 2005 Apr 20;53 (8) :2941-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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